Mechanism of Interactions of dsDNA Binding with Apigenin and Its Sulfamate Derivatives Using Multispectroscopic, Voltammetric, and Molecular Docking Studies
ACS OmegaSimon Waihenya, Pelin Şenel, Francis J Osonga, Taner Erdoğan, Filiz Altay, Ayşegül Gölcü, Omowunmi A Sadik
2021
DNA binding investigations are critical for designing better pharmaceutical compounds since the binding of a compound to dsDNA in the minor groove is critical in drug discovery. Although only one in-vitro study on the DNA binding mode of apigenin (APG) has been conducted, there have been no electrochemical and theoretical studies reported. We hereby report the mechanism of binding interaction of APG and a new class of sulfonamide-modified flavonoids, apigenin disulfonamide (ADSAM) and apigenin trisulfonamide (ATSAM), with deoxyribonucleic acid (DNA).
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Greener One-Pot Synthesis of Gold Nanoparticle Glycoconjugates Using Functionalized Sugars
ACS Agricultural Science & TechnologyIdris Yazgan, Francis J Osonga, Roland M Miller, Victor M Kariuki, Jing Zhang, Jun Feng, Zakiya Skeete, Heather Crapo, Jürgen Schulte, Omowunmi A Sadik
2021
Carbohydrates have been used to decorate metallic nanoparticles to form nanoglycoconjugates. However, the synthetic conditions typically require the utilization of increased temperatures and other reagents that negatively impact the stability of the conjugates. For the first time, this study is reporting the synthesis of gold–nanoparticle glycoconjugates (AuNP-GCs) in aqueous media at ambient temperatures.
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Novel quercetin and apigenin-acetamide derivatives: design, synthesis, characterization, biological evaluation and molecular docking studies
RSC AdvancesDaniel Isika, Mustafa Çeşme, Francis J Osonga, Omowunmi A Sadik
2020
Flavonoids exhibit essential but limited biological properties which can be enhanced through chemical modifications. In this study, we designed, synthesized and characterized two novel flavonoid derivatives, quercetin penta-acetamide (1S3) and apigenin tri-acetamide (2S3).
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Size and Shape-Dependent Antimicrobial Activities of Silver and Gold Nanoparticles: A Model Study as Potential Fungicides
MoleculesFrancis J Osonga, Ali Akgul, Idris Yazgan, Ayfer Akgul, Gaddi B Eshun, Laura Sakhaee, Omowunmi A Sadik
2020
Plant-based pathogenic microbes hinder the yield and quality of food production. Plant diseases have caused an increase in food costs due to crop destruction. There is a need to develop novel methods that can target and mitigate pathogenic microbes. This study focuses on investigating the effects of luteolin tetraphosphate derived silver nanoparticles (LTP-AgNPs) and gold nanoparticles (LTP-AuNPs) as a therapeutic agent on the growth and expression of plant-based bacteria and fungi.
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Synthesis, characterization and antifungal activities of eco-friendly palladium nanoparticles†
RSC AdvancesFrancis J Osonga, Sanjay Kalra, Roland M Miller, Daniel Isika, Omowunmi A Sadik
2020
Palladium is a versatile catalyst, but the synthesis of palladium nanoparticles (PdNPs) is usually attained at a high temperature in the range of 160 °C to 200 °C using toxic reducing agents such as sodium borohydride. We report the synthesis of PdNPs using a low-cost and environmentally-friendly route at ambient temperatures.
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